Forensics expert Lincoln Rhyme is called in to work the high-profile investigation of a killer who seemingly disappeared into thin air just as the NYPD closed in. As the homicidal illusionist baits him with grisly murders that grow more diabolical with each victim, Rhyme and his protegee, Amelia Sachs, must go behind the smoke and mirrors to prevent a horrific act of vengeance that could become the greatest vanishing act of all.